Transdermal delivery of Rauvolfia serpentina root extract for anxiety management
Author(s): Ariful Basher Abir, Md. Abdul Mannan and Shahadat Hossain
Abstract: Rauvolfia serpentina is a well-established herbal medicine for anxiety management for several years in Bangladesh. In attempted work, six patch formulations of
Rauvolfia serpentina root extract were formulated using Ethyl Cellulose (EC), Hydroxypropyl Methylcellulose (HPMC), Polyvinylpyrrolidone (PVP) and Polyvinyl acetate (PVA) in different ratios. Physicochemical characteristics and constant release profile was tested for all six formulations of four polymers.
In-vivo tests such, marble burying behavior (MBBT), locomotor activity (LAT), and skin irritation tests performed by applying the patches on rats for assays the anxiety management activity. Physicochemical characteristics such, weight uniformity, thickness, folding endurance, moister content, surface pH, swell ability, percent elongation of all the six formulations were 508.7 mg, 1.53 mm, 115.1, 4.91%, 6.06, 49.21% and 20% on an average of different formulations respectively with constant release of extract from each formulations. In MBBT, PF-I showed (
p<0.05) and PF-II – PF-IV showed (
p<0.01) significance, on the other hand in LAT, PF-II – PF-IV showed (
p<0.001) significance with zero skin irritation. Throughout the experiment, we developed herbal transdermal patches of
Rauvolfia serpentina root extract using different polymeric combinations, which reduced anxiety on rat models. As concluded, with further research herbal transdermal patch can be emerging as new and much convenient way of management anxiety.
DOI: 10.33545/27072827.2023.v4.i2b.95Pages: 104-110 | Views: 230 | Downloads: 118Download Full Article: Click Here
How to cite this article:
Ariful Basher Abir, Md. Abdul Mannan, Shahadat Hossain.
Transdermal delivery of Rauvolfia serpentina root extract for anxiety management. Int J Pharmacognosy Life Sci 2023;4(2):104-110. DOI:
10.33545/27072827.2023.v4.i2b.95
