2024, Vol. 5, Issue 2, Part A

Author(s): Malek Eleroui, Amal Feki, Asma Hamzaoui, Marwa Lakhrem, Marwa Kariem, Amal Dghim, Marwa Bouhamed, Choumous Kallel and Ibtissem Ben Amara

Abstract: The present study is aimed to evaluate in vivo the anti-inflammatory of methanolic extract of green algae Codium bursa (MEC) on carrageenan induced paw edema model in rats. The experimental protocol was performed on 20 rats divided in 4 groups: a control group, carrageenan-treated group (1%), the reference drug diclofenac sodium (DICLO 100 mg/kg) and MEC-treated group (50 mg/kg). The evaluation of the anti-inflammatory effect of MEC and DICLO was mainly evaluated by the measuring of edema paw swelling, hematological parameters, micronucleus test, oxidative stress assays, and histological evaluation. The pretreatment with MEC showed a significant (p <0:05) reduce of the inflammation symptoms such as the swelling of edema compared to the control group. The findings of this work demonstrated that MEC extract significantly minimized the lipid peroxidation and protein oxidation (TBARS, AOPP) and restored antioxidant enzymes activities in the inflamed tissues. Thereby, the anti-inflammatory capacity of MEC was confirmed with histological examination by establishing the normal microscopic structure in skin samples compared to the control and carrageenan groups. Hence, our results demonstrated that MEC could be used in the preparation of drugs destined on the treatment of acute inflammation.

DOI: 10.33545/27072827.2024.v5.i2a.124

Pages: 32-39 | Views: 247 | Downloads: 82

Download Full Article: Click Here